Its elimination halflife is 6 h, total clearance is 1.2 L/h, non-steady state apparent volume of distribution is 10.0 L and steady state apparent volume of distribution is 7.9 L. The converse is true when Iron is plentiful. Transferrin synthesis is increased and ferritin production reduced in Iron deficiency. The intracellular Iron becomes (mostly) haemoglobin in circulating red blood cells (RBCs). Transferrin without Iron (apotransferrin) is then released to the plasma. The transferrin receptor, located in the cell, and the transferrin-receptor complex is returned to the cell membrane. Iron binds to plasma transferrin, which carries Iron within the plasma and the extracellular fluid to supply the tissues. Ferritin, an Iron storage protein, binds and sequesters Iron in a nontoxic form, from which Iron is easily available. Following intravenous administration, Iron Sucrose Injection is dissociated into Iron and Sucrose by the reticuloendothelial system, and Iron is transferred from the blood to a pool of Iron in the liver and bone marrow. The drug product contains approximately 30% Sucrose w/v (300 mg/ml) and has a pH of 10.5-11.1. Iron Sucrose Injection USP is a brown, sterile, aqueous, complex of Polynuclear Iron (III) Hydroxide in Sucrose for Intravenous use. The therapeutic class of Iron Sucrose is haematinic.
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